The Perfect Enemy | 1st batch of Molnupiravir available at mainland hospitals as new option for COVID-19 patients - Global Times
February 2, 2023

1st batch of Molnupiravir available at mainland hospitals as new option for COVID-19 patients – Global Times

1st batch of Molnupiravir available at mainland hospitals as new option for COVID-19 patients  Global Times

Read Time:3 Minute

Molnupiravir Photo: VCG

The first batch of Molnupiravir, an antiviral medication developed by US company Merck Sharp & Dohme (MSD), has become available at a couple of hospitals across the Chinese mainland as a new option for COVID-19 patients. 

Over the past weekend, the first batch of Molnupiravir was delivered to several hospitals in Beijing, Shanghai, South China’s Guangdong Province and Southwest China’s Sichuan Province after the medicine, co-developed by MSD and Ridgeback Biotherapeutics, was given conditional market approval in the Chinese mainland on December 29, 2022.

So far, three oral antiviral medications for COVID-19 – Pfizer’s Paxlovid, China-developed Azvudine by Genuine Biotech and Molnupiravir – have become available in the Chinese market. 

Sinopharm, the medicine’s exclusive importer and distributor for the Chinese mainland, held a launch ceremony for Molnupiravir at a warehouse in the Waigaoqiao Free Trade Zone in Shanghai on Friday. 

With Sinopharm’s national distribution network and advantages in integrated control, the first batch of hundreds of thousands of packages of the medicine have been delivered to a couple of leading hospitals including Peking University First Hospital in Beijing, Shanghai East Hospital affiliated with Tongji University, Tianjin First Central Hospital, Chengdu Fifth People’s Hospital and The Third People’s Hospital of Shenzhen, according to media reports. 

According to China’s National Medical Products Administration, Molnupiravir capsules are oral small-molecule COVID-19 therapeutics for the treatment of mild- to moderate-adult patients with a high risk of progression to severe disease. Such patients include those with high risks such as obesity or being overweight, chronic kidney disease, diabetes, severe cardiovascular diseases and chronic obstructive pulmonary disease.

According to Lu Hongzhou, head of The Third People’s Hospital of Shenzhen, Molnupiravir has proven to be effective and safe when it is used at an early stage after the infection. 

Compared with Pfizer’s Paxlovid, which can interact with lots of medicines, Molnupiravir has an advantage in the treatment of the elderly, who often have underlying diseases and complications that have to be treated by many other medicines, Lu told the Global Times on Sunday. 

The first batch of Molnupiravir was reportedly delivered to Lu’s hospital on Saturday morning. 

According to a notification released by the Tianjin Medical Purchasing Center on January 10, the first batch of Molnupiravir is priced at 1,500 yuan ($222) per bottle. Sinopharm is working closely with MSD to promote supplies and has formulated plans for imports, warehousing and national delivery to meet the needs of grassroots medical and health institutions in various places during the upcoming Spring Festival holidays.

Molnupiravir received its first approval on November 4, 2021 in the UK for the treatment of mild to moderate COVID-19 in adults with a positive severe acute respiratory syndrome coronavirus 2 diagnostic test who have at least one risk factor for developing severe illness. 

It has obtained marketing authorization or emergency use authorization in more than 40 countries or regions including the US, Japan and members of the EU.

With the surge in infections, especially among the elderly, there is an increasing demand for oral medicines for the treatment of COVID-19. The launch of Molnupiravir in China is expected to expand the supply of oral medicines for COVID-19. 

Meanwhile, more medicines for COVID-19 are stepping up their entry into the market. 

According to Lu, there are a number of oral drugs currently in phase II or III clinical trials and many domestically developed oral drugs in clinical trials are expected to complete the process and hit the market soon.

A 3CL-targeting anti-SARS-CoV-2 drug candidate SIM0417, jointly developed by Nanjing-based Simcere Pharmaceutical Group, the Shanghai Institute of Materia Medica and the Wuhan Institute of Virology, is expected to be approved for the market in February, Jiangsu’s drug management authority announced in late December 2022.